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Research combining L-arginine with pycnogenol (a plant extract with antioxidant properties) showed more promising results than arginine alone, suggesting that addressing multiple pathwaysNO production and oxidative stressmay be more effective
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As IGF-1R mAbs are already in clinical trials, these observations warrant further exploration into the possible development of these drugs for safe and effective long-term use in humans as a strategy to delay at least some manifestations of aging
When the total mass of hepatocytes becomes too small to produce enough IGF-1 and store enough glycogen, glycemic control can become very problematic [24]
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