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Current mainstay interventions, including intensive lifestyle modification and bariatric surgery, demonstrate suboptimal and often unsustainable long-term efficacy in this genetically defined population, highlighting a critical unmet need for effective, accessible, and durable pharmacological strategies
Reduce inflammation Chronic inflammation is thought to play a central role in the development of conditions like heart disease, cancer, and diabetes
Automation of the CHARMM General Force Field (CGenFF) II: assignment of bonded parameters and partial atomic charges
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