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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

For others, it can take longer, especially if symptoms have been present for months or if there are multiple contributing factors (iron, vitamin D, thyroid issues, sleep, stress, etc.)

Minerva Med 8-31-1987;78(16):1255-1257

Too little vitamin B12 may leave your symptoms unresolved, while excessive amounts, although generally safe, can sometimes mask other medical issues or complicate long-term care