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Summary: Moderate calorie deficits (around 600 kcal/day below maintenance) pose minimal risk to immune function in healthy individuals, but severe or prolonged restriction can impair white blood cell production, antibody synthesis, and infection resistance

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In retatrutides TRIUMPH-1 trial, the highest-dose group reported nausea in 42.4% of participants, diarrhea in 32.0%, constipation in 26.1%, and vomiting in 25.3% a higher overall GI burden, which tracks with retatrutides larger effect size and third receptor target