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Among the main inflammatory mediators, CRP plays a crucial role in atherogenesis by promoting complement activation, enhancing macrophage lipid uptake, stimulating pro-inflammatory cytokine release, inducing monocyte tissue factor expression, impairing endothelial function, and inhibiting nitric oxide production, further aggravating vascular injury (Shrivastava et al

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Among nutritional supplements, oral glutathione and coenzyme Q10 were associated with improved outcomes (p=0.038 and p=0.011, respectively), while iron supplementation was associated with worse outcomes (p=0.006)

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