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The study published in The Lancet is a retrospective cohort study that looked at data from postmenopausal women who were overweight or obese and who took tirzepatide for 12 months or more
As patients often prefer oral medications due to their convenience, the adoption of such therapies could lead to better health outcomes across diverse populations
However, 80% of such mice displayed hindlimb paralysis and died with 8 weeks, therefore preventing us from proceeding further
Given that appetite and weight control will be key targets for an oral formulation, it is fortuitous that it is the stimulation of vagal afferents that has a direct impact on satiety effects of GLP1-RAs (Cork, 2018)
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