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Conservative starting doses would be essential: Initial phase : Cagrilintide 0.3 mg + Tirzepatide 2.5 mg weekly Escalation : Increase cagrilintide by 0.3-0.6 mg every 4 weeks Tirzepatide adjustment : Maintain or modestly increase based on tolerance Monitoring : Close observation for cumulative GI effects This remains speculative, as no published trials have examined this specific combination

for example, "Patient to receive weekly B12 injections for four weeks, followed by monthly maintenance." Follow-Up Visits : Schedule and document follow-up assessments

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Using them in separate routines (AM/PM) or on alternate days is safer for sensitive skin