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Non-targeted metabolomics analyses showed that platinum-resistant ovarian cancer cells have significantly reduced levels of GSH, which contributes to chemoresistance by forming adducts with cisplatin, leading to reduced intracellular concentrations of the active drug, and cisplatin-GSH adducts also reduce intracellular GSH levels

This is because your brain and body rely on glucose for energy, and when it drops too low, it triggers a stress response that includes nausea

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Variability and memory of protein levels in human cells