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But for the millions of men with obesity-related secondary hypogonadism, tirzepatide offers a fundamentally different and potentially superior approach
For type 2 diabetes , NICE recommends GLP-1 receptor agonists as second- or third-line therapy when metformin and other oral agents have not achieved adequate glycaemic control, or as an alternative to insulin in certain circumstances
Research endpoints include hepatic lipid accumulation, inflammatory signaling, insulin-pathway activity, and potential interactions between liver-specific responses and broader adipose-tissue changes
Mamane, Y., Petroulakis, E., LeBacquer, O
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