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However, due to the compensatory effect of intracellular GSH biosynthesis, GSH is hard to be completely exhausted and the strategy of GSH depletion remains challenging

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Therefore the overall impact on fertility that ROS has is not a matter of if it is there or not (as mentioned earlier, some oxidative stress is required for various reproductive physiological functions), but when levels of ROS are too high (or antioxidant levels are too low) it becomes pathological to sperm and the ability to get pregnant

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