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Nrf2 is involved in not only the regulation of GSH synthesis and reduction via upgrading some enzymes and proteins (SLC7A11, GCLM, GCLC, GR) but also the activation of GSH-dependent antioxidant enzymes (GPX, GST) [200, 201]

This was based on our previous reports that incubating primary murine Ms with oxLDL or cholesterol is a reproducible method of lipid loading Ms, and this significantly upregulated NRF2-dependent transcriptional regulation after LPS stimulation [6,25,26]

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L-carnitine: its investigational potential [PMID: 3788753] Laboratory literature summary: L-carnitine: its investigational potential