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These patients are now known in the medical world as long haulers due to their persistent symptoms long after contracting the virus and no longer testing positive
In line with strong and stable interactions of His1-Ala2 of GLP-1 compared with transient interactions of His1-Gly2 in exendin-4, truncation of these two N-terminal residues reduces GLP-1 affinity by 100300 fold, whereas for exendin-4, this has no effect, albeit, for both peptides, these residues are required for GLP-1R-mediated cAMP production 22,23,24,25
Lautenbach A, Wernecke M, Huber TB, et al
JAMA Psychiatry 82 , 888895 (2025)
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