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If your goal is 30, 50, or 100+ pounds, phentermine simply cannot get you there

Randomised withdrawal trials across this class consistently show substantial regain after discontinuation, with a 2026 review reporting that roughly two-thirds of lost weight is typically regained within a year of stopping, alongside reversal of some cardiometabolic improvements

While some early effects on blood sugar may appear within 2-4 weeks, meaningful improvements in hemoglobin A1c typically require 12-16 weeks at the maintenance dose

Frequent vomiting exposes your teeth to stomach acid, which can erode enamel and lead to tooth sensitivity and decay