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The guanidyl group of Arg132 helps stabilize the pentavalent transition state that yields the acyl-phosphate intermediate
Mitochondrial dysfunction in HD includes impaired electron transport chain activity, reduced mitochondrial biogenesis, and defective mitophagy, all of which contribute to increased oxidative stress and neuronal damage [165]
A TSH that has dropped from 2.1 to 0.8 mIU/L may not be clinically hypothyroid yet, but it warrants closer follow-up and potentially free T3/T4 measurement
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