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The older versions of these drugs were initially approved for the treatment of diabetes
Users who started at 6080mcg without titration report severe hypoglycemic episodes and injection site inflammation that forced protocol discontinuation
Bailey et al., Canadian Medical Association Journal , 2013 (grapefruit-drug interactions)
The gradual dose escalation strategy specifically aims to improve tolerability by allowing the digestive system to adjust to the medication's effects on gastric emptying and satiety signaling
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