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4.3.2 Methodological limitations and clinical strategies Existing studies generally treat pregnancy-related outcomes as secondary or exploratory endpoints and seldom report analyses stratified by weight-loss achievement, insulin-resistance improvement, or washout structure (111, 112, 124)

In addition, semaglutides interaction with GLP-1 receptors in the hypothalamus may mitigate sensations of hunger, alleviate food cravings and enhance the feelings of satiety

GLP-1 drugs may reduce pressure inside the skull by lowering the production of cerebrospinal fluid, which bathes the brain and spinal cord, the researchers suggested

Moreover, the effects of obesity on cardiovascular disease (CVD) are well-established [4, 5], and it is important to further demonstrate the importance of body weight loss interventions on the prevention of CVD