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Free Radic Biol Med 66:7587 Matsui M, Oshima M, Oshima H, Takaku K, Maruyama T, Yodoi J, Taketo MM (1996) Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene
Because of the longer half-life time compared to the alkoxyl radical, peroxyl radical is ideal for propagation of oxidative chain reactions, while the oxidation of alkoxyl radicals produce dihydroperoxide, which is degraded to toxic aldehydes, such as 4-hydroxy-2,3-trans-nonenal, 4-hydroxy-pentanal, short chain malondialdehyde
NAD+ levels fall in parallel, leaving cells with less capacity to power those same repair processes
10.1111/j.1744-7909.2010.00921.x 148 XuW
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