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Additionally, melatonin protects the BBB from methamphetamine damage by inhibiting nicotinamide adenine dinucleotide phosphate oxidase 2 via its receptors in these cells [187]

Along with the microglial foot processes and the basement membrane of the glia, astrocyte end-feet form the perivascular space border, which represents the last barrier to the entry of leukocytes and other infiltrating cells into the brain tissue (Man et al., 2007)

Physiciansmedical doctors (M.D.) and doctors of osteopathic medicine (D.O.)must complete four years of medical school and then undergo residency training