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While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort
Jr Natriuretic peptide based therapeutics for heart failure: cenderitide
Tomasello A et al
This receptor is the primary target of established therapies including semaglutide and liraglutide
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