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For instance, in September 2025, the World Health Organization (WHO) updated its Model Lists of Essential Medicines (EML)
Real-world weight-loss effectiveness of glucagon-like peptide-1 agonists among patients with type 2 diabetes: a retrospective cohort study
Amylin Pharmaceuticals was acquired by Bristol-Myers Squibb (and later AstraZeneca), and the Byetta/Bydureon franchise gradually declined by late 2010s as drugs like semaglutide took center stage
Nevertheless, lifestyle changes require stable and durable adaptation on a life-long basis, which remains difficult and challenging [31, 32]
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