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Leptin activates 5-AMP-activated protein kinase (AMPK) in muscle, inhibiting acetyl coenzyme A, an enzyme that catalyzes a key step in fat synthesis (Figures 1 and 2) (13-16)
How allodynia develops in the nervous system The mechanism behind allodynia involves two interconnected processes that researchers call peripheral sensitization and central sensitization
Most gastrointestinal side effects are mild to moderate in severity, though they lead to treatment discontinuation in approximately 5-10% of patients
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