In clinical trials, participants who took the highest dose of the once-daily pill achieved an average weight loss of 12.4 percent, or 27.3 pounds, after 72 weeks, compared with 2.2 pounds with the placebo
Other lipid-lowering therapies include: Ezetimibe : Reduces LDL cholesterol by approximately 1520% by inhibiting intestinal cholesterol absorption Bempedoic acid : Lowers LDL cholesterol by 15-25%, often used with ezetimibe when statins are contraindicated or not tolerated PCSK9 inhibitors : Achieve dramatic LDL reductions of 5060%, reserved for patients with very high cardiovascular risk or familial hypercholesterolaemia Fibrates : Primarily target triglycerides (reductions of 3050%) with modest effects on LDL cholesterol Icosapent ethyl : A prescription-grade omega-3 fatty acid that may be used in selected high-risk patients
Zhang L, Gong X, Tan J, Zhang R, Li M, Liu C, et al
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