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Primer sequences are detailed in Table S1

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If symptoms persist despite dose reduction, stopping ipamorelin temporarily may be necessary

Organisms have developed a highly conservative and complex molecular clock system, which creates an internal circadian rhythm during light/dark input ( SCN may act on somatostatinergic neurons and GH-releasing hormones (GHRH) to synchronize the GH rhythm with the light-dark cycle (Willoughby and Martin, 1978