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A concentration-response design, vehicle-matched control, target-engagement marker, and parallel genetic or pharmacological validation can strengthen attribution to NNMT biology

Both protocols use gradual titration to minimize gastrointestinal side effects

Other types of environmental pollutants include organotins, widely used antifouling biocides for ships and fishing nets, play a role as endocrine disruptors as they bind to PPAR/RXR, induce adipogenesis, and repress inflammatory genes in different mammalian cells [195]