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Since mitochondrial oxidative phosphorylation depends on local NADH availability, whereas cytosolic NADPH supports reductive buffering, disproportionate redistribution between compartments may amplify localized redox imbalance even when total cellular NAD levels appear preserved
This helps the body burn fat more efficiently and increases energy balance throughout the day
The two drugs are metformin, one of the most widely used diabetes medications, and the GLP-1 class of medications that include Ozempic, Mounjaro and Saxenda
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