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At regular doses, semaglutide and tirzepatide are associated with tolerability issues in some patients, particularly gastrointestinal side effects
A review from 2015 demonstrated that sitagliptin can effectively reduce HbA1c levels starting from the first week of treatment, has a side effect profile comparable to placebo, making it generally well-tolerated even amongst elderly populations
29,30 Caution has been advocated for the use of these medications in patients with HFrEF
The lipotropic effect of protein. Nature 135.3420 (1935): 821-822
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