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These include: Nausea (often most pronounced during dose escalation) Vomiting and diarrhoea Constipation Abdominal discomfort and bloating Reduced appetite (therapeutic effect but may be excessive) These symptoms typically diminish over 48 weeks as tolerance develops
Measurement of GSH in plasma Peripheral whole-blood samples were collected from each participant by venous puncture (Supplementary Table 1)
And a small randomized clinical trial found patients with opioid use disorder who took an older form of GLP-1 known as liraglutide experienced a 40 percent reduction in opioid cravings compared with a placebo
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