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2019;180(3):e71-e71

In parallel, metabolic modulators such as metformin, dapagliflozin, and glucagon-like peptide-1 receptor agonists reprogram ovarian bioenergetics by reshaping substrate utilization, suppressing inflammatory and oxidative signaling, and improving mitochondrial efficiency within the ovary

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However, some individuals may experience: Injection site reactions such as mild redness, itching, or swelling Water retention or mild fluid buildup, particularly in the early weeks Joint discomfort or stiffness, which often resolves as the body adjusts Tingling or numbness in the hands or feet (less common) Elevated blood glucose levels in individuals predisposed to insulin resistance It is worth noting that tesamorelin should not be used by individuals with active cancer, those who are pregnant, or patients with hypersensitivity to its components