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214 Alzheimers disease (AD) Alzheimers disease (AD) is characterized by senile plaques and neurofibrillary tangles (NFTs) caused by amyloid- and phosphorylated tau deposition
Heme oxygenase 1 catalyzes the degradation of heme to free iron, biliverdin, and carbon monoxide (CO) thereby removing free heme which is pro-oxidant
It provides the same level of performance, but is easier to handle as it eliminates the need to adjust the masking solution
Co-formulation approaches such as SNAC address stability and absorption at the site of dosing, shaping how the molecule reaches circulation
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