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First, most of the included studies rely on observational data, which inherently limits causal inference (Table 2)

Injectable medications are allowed through TSA checkpoints

Treatment is HSA/FSA eligible, making it accessible regardless of insurance status

In STEP 1, the pivotal trial behind modern semaglutide, 1,961 adults with overweight or obesity and without diabetes were randomized 2:1 to semaglutide 2.4 mg or placebo

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