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A histidine at the second position, combined with the N-terminal amine and a backbone nitrogen, produces a three-point binding site with high affinity for copper(II)
At the time of the respective regulatory submissions, the EMA required an LOCF-based approach [36] whereas the FDA requested an MI approach [37]
Anti-aging applications The combination of collagen stimulation, antioxidant activity, and cell-protective effects makes copper peptides relevant for anti-aging protocols
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