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According to research, the two notable modifications include the substitution of methionine and L-phenylalanine at the fourth and seventh positions with norleucine and D-phenylalanine, respectively
Their structural resemblance to biological membranescomprising phospholipids and cholesterol, confers enhanced biocompatibility and facilitates efficient transfollicular drug delivery [213, 214]
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The practical takeaway is that formulation quality and delivery method are not minor details, they are part of whether the peptide does anything at all
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