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Semaglutide's main risks involve gastrointestinal tolerance and rare pancreatitis concerns, but it improves heart health markers in most patients
Tirzepatide also induced greater reductions in fat mass compared to placebo and semaglutide
Hypotheses include medication-related blood pressure changes, volume depletion from gastrointestinal effects, rapid glycemic improvement leading to transient vascular dysregulation, and altered autoregulation of optic nerve head perfusion
For datasets with overlapping populations, we ensured that only the non-overlapping subset was included in the meta-analysis to avoid duplication bias
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