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A 2003 prospective cohort study by Khavinson and Morozov found that epithalon had the following effects when administered to a sample of 266 adults over the age of 60 [9]: Decreased incidence of ischemic heart disease Decreased incidence of hypertension disease Lowered rates of deforming osteoarthritis and osteoporosis More recently, a 2020 study by Khavinson et al

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79 Chronic hyperglycemia activates mTORC1 and reduces mTORC2 activity 157 in islet cells, which leads to the translocation of FOXO1 to nucleus and less nuclear PDX1, resulting in reduced insulin synthesis and secretion and impaired cell mass 80,158 (Fig