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Our results provide a possible mechanism in which upregulation of phosphorylated p53 and p16 maintain the cell cycle arrest of keloid fibroblasts, and FOXO4-DRI selectively induces apoptosis of keloid senescent fibroblasts by prompting p53-pS15 nuclear exclusion
The derived formula provides a unique way for predicting the concentration of H 2 O 2 and the activity of GPxs and Prxs and how a change in any of the antioxidants affects the overall rearrangement of antioxidant activity
In this study, a dual stimuli-responsive prodrug nanosystem (MSNs-ss-SA) was synthesized by conjugating SA to functionalized disulfide-doped mesoporous silica nanoparticles (MSNs-ss-NH 2 ) via amide bonds to facilitate the efficient delivery of SA and bioavailable silicon concurrently
Dihexa was administered intraperitoneally (i.p.) at 0.5 mg/kg in phosphate buffered saline (PBS) on alternate days, commencing 15 days post-surgery and continuing through day 48, with control animals receiving PBS alone
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