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Researchers looked at data from more than 430,000 patients aged 50 and older who took either a GLP-1, sodium-glucose cotransporter 2 inhibitors (SGLT2i), metformin or insulin to manage their diabetes for at least two years

Aging Clin Exp Res 33:28872898 Prasada Kabekkodu S, Chakrabarty S, Jayaram P, Mallya S, Thangaraj K, Singh KK, Satyamoorthy K (2023) Severe acute respiratory syndrome coronaviruses contributing to mitochondrial dysfunction: implications for post-covid complications

This high overall GI rate (while mostly mild) likely reflects the combined GI effects of activating both GLP-1 and amylin pathways simultaneously