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In a post hoc analysis of the SUSTAIN 6/PIONEER 6 trials including pooled data from 6480 participants at high cardiovascular risk, there was a significant difference in the estimated treatment effect (semaglutide versus placebo) on eGFR slope: 0.59ml/min/1.73m2 (95% CI: 0.290.89).56,93 This effect was numerically largest in subjects with an eGFR between 30 and 60ml/min per 1.73m2 [1.06ml/min/1.73m2 (95% CI: 0.451.67)], but without significant interaction for treatment effect by subgroup
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Chiang P-C, Deshmukh G, Liu J, Nagapudi K, Chen JZ, Valle N, Li R, Plise EG, Durk MR
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