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Key warning signs that warrant medical attention include: Persistent low mood or sadness lasting more than two weeks Loss of interest in previously enjoyed activities Changes in sleep patterns either insomnia or excessive sleeping Significant anxiety or agitation that interferes with daily functioning Thoughts of self-harm or suicide , even if fleeting Feelings of hopelessness or worthlessness Social withdrawal from family and friends Difficulty concentrating or making decisions Immediate action is required if you or someone you know experiences active suicidal thoughts, plans for self-harm, or believes they might act on suicidal ideation

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This gives healthcare providers a lot more flexibility with dosing schedules