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doi: 10.1016/j.molcel.2011.10.021 33 YangGZhaoKJuYManiSCaoQPuukilaSet al

This is where it gets interesting

These include heightened endogenous opioid production and the activation of -opioid receptors, instigating itching by attenuating pain signaling

This agrees with the clinical impression that total compression of the sclerosed vessel is necessary for ideal, long-lasting, and complication-free sclerosis