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For treatment of T2D amongst patients without pre-existing cardiovascular or renal complications who are not adequately controlled on metformin (with or without sulfonylurea), in order to reduce HbA1c levels, international [13] and Danish [14] guidelines recommend intensifying with anti-diabetic treatment options such as dipeptidyl peptidase-4 inhibitors (DPP4is), sodiumglucose cotransporter 2 inhibitors (SGLT-2is) and glucagon-like peptide 1 receptor agonists (GLP-1RAs)

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alleviating the symptoms of P, K, and Ca deficiency (Hu et al., 2021

No cases of anaphylaxis or life-threatening allergic reactions have been reported in the retatrutide trial literature