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(2012), in their study, reported that 22 out of 33 male patients with severe idiopathic oligoasthenoteratozoospermia (OAT) of infertile couples whose partners had undergone at least one ICSI cycle, showed reduced sperm aneuploidy levels (assessed using fluorescent in situ hybridization performed on chromosomes X, Y, 13, 15, 16, 17, 18, 21 and 22) and improved sperm morphology after 3 months of treatment with LC 2 1 g/day, ALC 2 500 mg/day and cinnoxicam (a lipophilic NSAID) 1 30 mg/every 4 days [89]
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Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, making this finding especially relevant for clinical application
Furthermore, PSAT1 regulates changes in the level of glutamine-derived -KG, which controls mESC pluripotency and differentiation 106
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