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According to Table 1, comprehensive experimental and observational studies reveal that GLP-1RAs do not elevate overall cancer risk, while preclinical investigations have demonstrated multiple anti-tumor mechanisms, including proliferation inhibition, apoptosis induction, and metastasis suppression
Kinetics and mechanisms of thiol-disulfide exchange covering direct substitution and thiol oxidation-mediated pathways
The concentration of produced ammonia was detected using an Ammonia Assay Kit (Abcam, Cambridge, UK) according to the manufacturers instructions
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