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Analysis of weight management trials found that only 4.3% of participants permanently discontinued semaglutide 2.4 mg due to gastrointestinal adverse events, with most discontinuations occurring during the dose escalation phase
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Studies suggest that up to 25 to 40% of the weight lost during GLP-1 therapy may come from lean mass, primarily skeletal muscle, if active steps are not taken to preserve it [23]
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