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If constipation-predominant IBS worsens significantly or diarrhea-predominant IBS shifts to severe constipation, medication adjustment may be necessary
Cautionary Voices from Experts While the idea of GLP1 agonism induction of depression and SI is controversial with both negative and positive reporting, based on the evidence presented in this article by Alireza Sharafshah, a PhD candidate from Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, the authors caution against promoting chronic stimulation via GLP-1 agonists
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