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For example, LNPs were formulated with galactosylated lipids to target asialoglycoprotein receptors on hepatocytes, enabling efficient delivery of siRNA to liver metastases [231]

We'll tell you what the research showsand what it doesn't

We were looking at these rodent studies, and were like, these look really promising. And were doing the math on species conversions to figure out human doses. Nobody was under the illusion that what they were doing was definitively safe, he continued

115 Another significant intracellular source of ROS is the NOXs, especially in response to physiological stimuli, including growth factors, hormones and cytokines, and pathological impulse, such as bacterial and viral infections