how does glp 1 lower inflammation 🔴The benefits of GLP-1 drugs beyond obesity! 🔹New #OpenAccess #Review 🔹The actions of GLP-1 medicines:- 1️⃣GLP-1 exerts direct and indirect actions to reduce glucose and body weight. 2️⃣GLP-1 attenuates indirectly through Beyond Weight Loss: How GLP-1

When activated, these receptors trigger several beneficial effects: Enhanced insulin secretion in response to elevated blood glucose levels Suppression of glucagon release , reducing hepatic glucose production Delayed gastric emptying , which promotes satiety and reduces appetite Direct effects on appetite centres in the hypothalamus, leading to reduced food intake Commonly prescribed GLP-1 receptor agonists available in the UK include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and exenatide (Byetta, Bydureon)

they're going to work on the brain too

Red blood cells: a source of extracellular vesicles

Exenatide (shown on the right, PDB 7LLL), which was the first GLP-1 receptor agonist approved by the FDA, shares just over 50% sequence identity with GLP-1, but has a similar structure and is able to activate the GLP-1 receptor, while avoiding rapid proteolytic degradation