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The Injection May Still Be Better For Patients Seeking Maximum Weight Loss Current evidence still favors injectable semaglutide for peak average weight reduction
References include the SURMOUNT-1 trial publication (Jastreboff et al., New England Journal of Medicine, 2022), the Mounjaro and Zepbound prescribing information (Eli Lilly, 2024), Liu et al., JAMA Internal Medicine, 2018 (steroid-induced hyperglycemia), and American Diabetes Association Standards of Care, 2024
Many patients are unable to tolerate metformin for this reason
These effects are similar to those observed with other poorly absorbed carbohydrates, such as sugar alcohols (polyols)
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