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The following study noted systemic iron depletion from curcumin (the most active constituent of turmeric): Curcumin has chemical properties consistent with iron chelator activity
The most frequently reported reactions include: Redness (erythema) at the application site Itching or a tingling/stinging sensation , especially on freshly exfoliated or compromised skin Dryness or mild flaking , sometimes related to the overall formulation rather than the peptide itself Temporary irritation when combined with strong actives These reactions typically resolve on their own or after reducing frequency of use
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