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The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
e0162590
examined the formation of DNA cross-links in a panel of 9 human tumor cell lines, treated with PR-104A, the active form of the hypoxia-activated prodrug PR-104, and their relationship to hypoxia, bioreductive metabolism, and cytotoxicity
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