Though with similar effects as some pre-existing drugs (semaglutide, liraglutide, exenatide, etc.) targeting diabetes and obesity, tirzepatide is considered a first-in-class medication for demonstrating action on both the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors
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Agents such as quercetin, jujuboside A, cornuside, boeravinone C, cycloastragenol, and the JinChan YiShen TongLuo formula have been demonstrated to block TECs apoptosis through modulating mitochondrial function, ER stress, or key signaling pathways (117, 120, 128131), exhibiting promising translational potential